comparision of the efficacy of nebulized l-epinephrine, salbutamoland normal saline in acute bronchiolitis: a randomized clinical trial
نویسندگان
چکیده
abstract background: acute bronchiolitis is the most common form of lower respiratory tract infection in infancy. there are numerous contradictory reports regarding the efficacy of nebulized bronchodilators in the management of infants with acute bronchiolitis. this study was designed to compare the efficacy of nebulized epinephrine with salbutamol for treatment of the disease. methods: in a randomized clinical trial, 72 infants with moderately severe bronchiolitis were enrolled in three equal groups. three doses of epinephrine, salbutamol, and normal saline as a placebo nebulized with oxygen were given at 20 minute intervals. oxygen saturation, respiratory rate and distress were recorded before intervention and i0 minutes after each dose of the drugs. results: at the end of the study, pre- and post-treatment mean oxygen saturation values, clinical scores and respiratory rates showed significant differences between the epinephrine and salbutamol groups in comparison with the placebo group. the results were more significant in the epinephrine group than other groups. after the treatment course 66%, 50%, and 25% of patients in epinephrine, salbutamol, and placebo groups respectively showed significant improvement at a degree that they could be sent home. no serious side effects were observed. conclusion: both nebulized epinephrine and salbutamol improved oxygenation and decreased respiratory distress better than normal saline. l-epinephrim was more effective in relieving respiratory distress and improving oxygen saturation as well as the need for hospitalization than nebulized salbutamol.
منابع مشابه
COMPARISION OF THE EFFICACY OF NEBULIZED L-EPINEPHRINE, SALBUTAMOLAND NORMAL SALINE IN ACUTE BRONCHIOLITIS: A RANDOMIZED CLINICAL TRIAL
ABSTRACT Background: Acute bronchiolitis is the most common form of lower respiratory tract infection in infancy. There are numerous contradictory reports regarding the efficacy of nebulized bronchodilators in the management of infants with acute bronchiolitis. This study was designed to compare the efficacy of nebulized epinephrine with salbutamol for treatment of the disease. Methods: In a r...
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متن کاملEpinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial
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متن کاملNebulized hypertonic saline for bronchiolitis: a randomized clinical trial.
IMPORTANCE Bronchiolitis is one of the most common and costly respiratory diseases in infants and young children. Previous studies have shown a potential benefit of nebulized hypertonic saline; however, its effect in the emergency department (ED) setting is unclear. OBJECTIVE To compare the effect of nebulized 3% hypertonic saline vs 0.9% normal saline on admission rate and length of stay in ...
متن کاملNebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial.
IMPORTANCE Acute bronchiolitis is the most frequent lower respiratory tract infection in infants, yet there are no effective therapies available. Current evidence is unclear about the role of hypertonic saline (HS) for the acute treatment of bronchiolitis. OBJECTIVE To determine whether nebulized 3% HS compared with normal saline (NS) improves respiratory distress in infants with bronchioliti...
متن کاملA randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis.
OBJECTIVE To determine if nebulized epinephrine is more efficacious than nebulized albuterol in the emergency department (ED) treatment of moderately ill infants with bronchiolitis. METHODS Sixty-six patients between 0 and 12 months of age with new-onset wheezing, an antecedent upper respiratory tract infection, and a clinical score (Respiratory Distress Assessment Instrument) of 8 to 15 were...
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عنوان ژورنال:
medical journal of islamic republic of iranجلد ۱۹، شماره ۲، صفحات ۱۱۹-۱۲۵
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